Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications

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dc.contributorJayabalan, M.
dc.contributorShalumon, K. T.
dc.contributorMitha, M. K.
dc.contributorGanesan, K.
dc.contributorEpple, M.
dc.date.accessioned2012-12-04T11:43:57Z
dc.date.available2012-12-04T11:43:57Z
dc.date.issued2010
dc.description.abstractThe effect of hydroxyapatite (HAP) on the performance of nanocomposites of an unsaturated polyester, i.e. hydroxy-terminated high molecular weight poly(proplyene fumarate) (HT-PPFhm), was investigated A thermoset nanocomposite was prepared with nanoparticles of calcined HAP (<100 nm, rod-like shape, filler content 30 wt %), HT-PPFhm and N-vinyl pyrrolidone, dibenzoyl peroxide and N,N-dimethyl aniline. Two more nanocomposites were prepared with precipitated HAP nanoparticles (<100 nm rod-like shape) and commercially available HAP nanoparticles (<200 nm spherical shape), respectively Calcined HAP nanoparticles resulted in very good crosslinking in the resin matrix with high crosslinking density and Interfacial bonding with the polymer. owing to the rod-like shape of the nanoparticles, this gave improved biomechanical strength and modulus and also controlled degradation of the nanocomposite for scaffold formation The tissue compatibility and osteocompatibility of the nanocomposite containing calcined HAP nanoparticles was evaluated The tissue compatibility was Studied by Intramuscular implantation in a rabbit animal model for 3 months as per ISO standard 10993/6 The in vivo femoral bone repair was also carried out in the rabbit animal model as per ISO standard 10993/6 The nanocomposite containing calcined HAP nanoparticles is both biocompatible and osteocompatible (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved.
dc.identifier.citationACTA BIOMATERIALIA. 6; 3; 763-775en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.actbio.2009.09.015
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/410
dc.publisherACTA BIOMATERIALIA
dc.subjectBiocompatibility
dc.titleEffect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications
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