Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair

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dc.contributor.authorNair, MB
dc.contributor.authorVarma, HK
dc.contributor.authorJohn, A
dc.date.accessioned2017-03-10T03:29:06Z
dc.date.available2017-03-10T03:29:06Z
dc.date.issued2009
dc.description.abstractCurrent treatment strategies for the repair or replacement of bone use synthetic implants with stem cells and their progeny--a new approach to address unmet medical needs. This study has evaluated the effect of a silica-coated bioactive ceramic, namely HASi in comparison to hydroxyapatite (HA) on the adhesion, proliferation and osteogenic differentiation of goat bone marrow-derived mesenchymal stem cells in vitro in a prolonged culture of 28 days. The cellular activities were significantly enhanced on HASi signifying the role of silica to stimulate osteoblast cells. The fabrication of such a 'cell-ceramic construct using autologous MSCs' is aimed for the transplantation to a large bone defect site in the goat femur model which still remains a formidable challenge in Orthopedic surgery.
dc.identifier.citation20 ,;251-258en_US
dc.identifier.uri10.1007/s10856-008-3598-8
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10632
dc.publisherJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
dc.subjectEngineering; Materials Science
dc.titleTriphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair
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