Circulating Thrombotic Risk Factors in Young Patients with Coronary Artery Disease Who Are on Statins and Antiplatelet Drugs
No Thumbnail Available
Date
2016-02
Journal Title
Journal ISSN
Volume Title
Publisher
Ind J Clin Biochem
Abstract
Thrombotic risk factors may contribute to
premature coronary artery disease (CAD), in addition to the
conventional risk factors. There is paucity of data on
studies evaluating the role of thrombotic factors in premature
CAD in Indian patients. Thus a case–control study
was performed to evaluate the role of thrombotic and
atherogenic factors in young patients with angiographically
proven CAD who are on treatment with statins and antiplatelet
drugs. 152 patients (B55 years) with angiographically
proven CAD and 102 asymptomatic controls were
recruited. Clinical and biochemical data were obtained in
both groups. Blood levels of thrombotic factors-fibrinogen,
antithrombin-III, tissue-plasminogen activator (t-PA),
plasminogen activator inhibitor-1 (PAI-1), von-Willebrand
factor (v-WF), lipoprotein(a) [Lp(a)] and homocysteine
were analyzed. Patients had high levels of conventional
CAD risk factors (diabetes mellitus, smoking, hypertension,
dyslipidemia and positive family history) compared to
controls. Logistic regression analysis revealed that low
antithrombin-III (odds ratio/OR 11.2; 95 % confidence
interval/CI 2.29–54.01), high fibrinogen (OR 6.04; 95 %
CI 1.09–33.21) and high Lp(a) (OR 4.54; 95 % CI
0.92–22.56), as important, independent risk factors in
patients. PAI-1(OR 0.15; 95 % CI 0.03–0.69) levels were
significantly lower in patients. But other thrombotic risk
factors studied (t-PA, v-WF and homocysteine) were
comparable among patients and controls. The treatment
using statins and anti-platelet drugs might be contributing
to the control of some of the thrombotic risk factors. The
strategies aiming at lowering the levels of thrombotic risk
factors along with conventional risk factors may be useful
in primary and secondary prevention of CAD
Description
Keywords
Coronary artery disease (CAD) Premature CAD Thrombotic factors India I
Citation
Reema G, Harikrishnan S, Jayakumari N, Anugya B, Jissa VT, Tharakan JA . Circulating Thrombotic Risk Factors in Young Patients with Coronary Artery Disease Who Are on Statins and Antiplatelet Drugs. Ind J Clin Biochem. 2016