Role of PEGylated CdSe-ZnS quantum dots on structural and functional properties of electrospun polycaprolactone scaffolds for blood vessel tissue engineering

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dc.contributor.authorSoumya, Columbus
dc.contributor.authorDiksha, Painuly
dc.contributor.authorRenjith P, Nair
dc.contributor.authorKalliyana Krishnan, V
dc.date.accessioned2021-10-01T07:22:57Z
dc.date.available2021-10-01T07:22:57Z
dc.date.issued2021-05
dc.description.abstractConjugation of quantum dots (Q-dots) into tissue engineering scaffolds is extremely beneficial for designing composite scaffolds imparting multifunctional properties. In the present work, we report the efficacy of incorporating the PEGylated CdSe-ZnS (Q-dots) into electrospun poly(caprolactone)(PCL) scaffolds whose properties were evaluated for small diameter blood vessel applications. Incorporation of Q-dots was found to result in significant reduction in fiber diameter of electrospun scaffolds. Corresponding pore size ranges varied from 12 to 36 µm for composite scaffold compared with 12–60 µm in bare scaffold. Both PCL and composite scaffolds were found to possess better mechanical strength and elasticity than that of native arteries. Contact angle measurements revealed hydrophobic nature of scaffolds which significantly improved upon modification with fibrin. PCL/Q-dot composite scaffolds were found to possess optimum micro-structure for supporting uniform endothelial cell growth after 5 days of culture compared to the pristine PCL scaffold.en_US
dc.identifier.citationSoumya Columbus, Diksha Painuly, Renjith P Nair and Kalliyana Krishnan.V. Role of PEGylated CdSe-ZnS quantum dots on structural and functional properties of electrospun polycaprolactone scaffolds for blood vessel tissue engineering. European Polymer Journal. 2021 May 31; 151:110430en_US
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2021.110430
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/11058
dc.publisherEuropean Polymer Journal.en_US
dc.titleRole of PEGylated CdSe-ZnS quantum dots on structural and functional properties of electrospun polycaprolactone scaffolds for blood vessel tissue engineeringen_US
dc.typeArticleen_US
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