Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kappa B in colon cancer cells

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dc.contributorBabykutty, Suboj
dc.contributorPriya, P. S.
dc.contributorNandini, R. J.
dc.contributorKumar, M. A. Suresh
dc.contributorNair, Mangalam S.
dc.contributorSrinivas, Priya
dc.contributorGopala, Srinivas
dc.date.accessioned2012-12-04T11:44:43Z
dc.date.available2012-12-04T11:44:43Z
dc.date.issued2012
dc.description.abstractNimbolide, a plant-derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition of cyclin A leading to S phase arrest. It also caused activation of caspase-mediated apoptosis through the inhibition of ERK1/2 and activation of p38 and JNK1/2. Further nimbolide effectively retarded tumor cell migration and invasion through inhibition of metalloproteinase-2/9 (MMP-2/9) expression, both at the mRNA and protein level. It was also a strong inhibitor of VEGF expression, promoter activity, and in vitro angiogenesis. Finally, nimbolide suppressed the nuclear translocation of p65/p50 and DNA binding of NF-?B, which is an important transcription factor for controlling MMP-2/9 and VEGF gene expression. (C) 2011 Wiley Periodicals, Inc.
dc.identifier.citationMOLECULAR CARCINOGENESIS. 51; 6; 475-490en_US
dc.identifier.urihttp://dx.doi.org/10.1002/mc.20812
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/795
dc.publisherMOLECULAR CARCINOGENESIS
dc.subjectOncology
dc.titleNimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-kappa B in colon cancer cells
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