Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.

dc.contributor	Krishnan, V V
dc.contributor	Saraswathy, A
dc.date.accessioned	2012-12-04T11:43:57Z
dc.date.available	2012-12-04T11:43:57Z
dc.date.issued	1994
dc.description.abstract	Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.
dc.identifier.citation	Indian journal of experimental biology. 32; 6; 405-8	en_US
dc.identifier.uri	https://dspace.sctimst.ac.in/handle/123456789/415
dc.publisher	Indian journal of experimental biology
dc.subject	Experimental Medicine
dc.title	Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.