Superoxide-mediated activation of cardiac fibroblasts by serum factors in hypomagnesemia
| dc.contributor | Kumaran, C | |
| dc.contributor | Shivakumar, K | |
| dc.date.accessioned | 2012-12-04T11:45:22Z | |
| dc.date.available | 2012-12-04T11:45:22Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | Magnesium deficiency is known to produce myocardial fibrosis in different animal models, but the underlying mechanisms are unclear. However, circulating levels of pro-oxidant and mitogenic factors are reported to be elevated in a rodent model of acute magnesium deficiency, suggesting a role for humoral factors in the pathogenesis of the cardiovascular lesions. Probing the mechanism of cardiac fibrogenesis in magnesium deficiency, the present study furnished evidence that serum from magnesium-deficient rats has a more marked effect than serum from magnesium-sufficient rats on mitogenesis, net collagen production, and superoxide generation in cardiac fibroblasts from young adult rats. The enhanced mitogenic response was abolished by superoxide dismutase and N-acetyl cysteine, showing that it is mediated by superoxide anion. Further, a modest inhibitory effect of the neurokinin-1 receptor antagonist, spantide, suggested that factors acting via neurokinin-1 receptors may partly modulate cardiac fibroblast function in magnesium deficiency. The findings are consistent with the postulation that serum factors may activate cardiac fibroblasts via a superoxide-mediated mechanism and contribute to the fibrogenic response in the heart in magnesium deficiency. (C) 2001 Elsevier Science Inc. | |
| dc.identifier.citation | FREE RADICAL BIOLOGY AND MEDICINE. 31; 7; 882-886 | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/S0891-5849(01)00656-6 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/11585706 | |
| dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/1117 | |
| dc.publisher | FREE RADICAL BIOLOGY AND MEDICINE | |
| dc.subject | Cardiology | |
| dc.title | Superoxide-mediated activation of cardiac fibroblasts by serum factors in hypomagnesemia |