Alterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats - Implications for the pathogenesis of endomyocardial fibrosis

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dc.contributor.authorKumar, BP
dc.contributor.authorShivakumar, K
dc.date.accessioned2017-03-10T03:25:23Z
dc.date.available2017-03-10T03:25:23Z
dc.date.issued1998
dc.description.abstractCerium (Ce), a rare earth element, has been postulated to play a role in the pathogenesis of tropical endomyocardial fibrosis (EMF). Investigations carried out recently in pursuance of the postulation furnished histological evidence of EMF and increased cardiac collagen content in rats on prolonged administration of Ce. The present study was undertaken to understand the molecular basis of myocardial injury and fibrosis produced by the element. This article presents evidence of increased lipid peroxidation and elevated rates of fibroblast proliferation and collagen deposition in the heart in Ce-treated rats. It is suggested that the element may trigger a wound-healing response in the cardiac tissue leading to cardiac fibrosis.
dc.identifier.citation63 ,1;73-79en_US
dc.identifier.uri10.1007/BF02785279
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9260
dc.publisherBIOLOGICAL TRACE ELEMENT RESEARCH
dc.subjectBiochemistry & Molecular Biology; Endocrinology & Metabolism
dc.titleAlterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats - Implications for the pathogenesis of endomyocardial fibrosis
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