Long term surgical outcomes of Medulloblastoma – A single institution experience

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Medulloblastoma is the most common childhood malignant tumour of the brain and accounts for 20% of CNS tumours in children. These tumours are grouped into four morphological types viz 1. classical type, 2. desmoplastic nodular, 3. with extensive nodularity; 4. anaplastic/large cell variety. Based on molecular profile, Medulloblastoma has been reclassified into four subtypes: They are Wingless(WNT), Sonic hedgehog(SHH), Group 3 and Group 4 types. Medulloblastomas are risk stratified based on various factors into standard/average risk and high risk, according to clinical risk factors, histological features, molecular markers, age at diagnosis, extent of tumour resection and presence or absence of metastases. The main form of treatment for this condition is surgical resection followed by adjuvant therapies like chemotherapy and craniospinal radiotherapy. The main drawbacks of this treatment are significant side effects and long-term impairment due to adjuvant therapy and the morbidity related to surgery. Hence, we aimed to study this tumour in all aspects- clinico demographic profile, imaging characteristics, post operative complications, cerebellar mutism, recurrence, functional outcomes on follow up. In a small cohort of patients, we had a molecular data regarding the immunohistochemistry for small cohort of patients which was compared with Morphological type. This is one among the largest series of Medulloblastoma study in the world literature and maximum cases recorded from a single institute in India. Acknowledgement : Krishnakumar K1 , Easwer HV, George C.Vilanilam, Jayanand B Sudhir, Prakash Nair, Ganesh Divakar, Gowtham M, Deepthi N2, Rajaleksmy P2, Kesavadas C3, Bejoy Thomas3 ( 1=Department of Neurosurgery, 2= Department of Pathology, 3 = Department of IS & IR)