Infiltration and sustenance of viability of cells by amphiphilic biosynthetic biodegradable hydrogels

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dc.contributor.authorThankam, FG
dc.contributor.authorMuthu, J
dc.date.accessioned2017-03-10T03:27:17Z
dc.date.available2017-03-10T03:27:17Z
dc.date.issued2014
dc.description.abstractAmphiphilic biosynthetic hydrogels comprising natural polysaccharide alginate (I) and synthetic polyester polypropylene fumarate (II) units were prepared by crosslinking the copolymer of I and II with calcium ion and vinyl monomers viz, 2-hydroxyethyl methacrylate (HEMA), methyl methacrylate (MMA), butyl methacrylate (BMA) and N,N'-methylene bisacrylamide (NMBA). Three fast degradable hydrogels, ALPF-MMA, ALPF-HEMA and ALPF-BMA and one slow degradable hydrogel ALPF-NMBA were prepared. These hydrogels are amphiphilic and able to hold sufficient amount of proteins on their surfaces. All these hydrogels are found to be hemocompatible, cytocompatible and genocompatible. ALPF-NMBA promotes infiltration of L929 fibroblasts and 3D growth of H9c2 cardiomyoblasts and long-term viability.
dc.identifier.citation25 ,8;1953-1965en_US
dc.identifier.uri10.1007/s10856-014-5234-0
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9931
dc.publisherJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
dc.subjectEngineering; Materials Science
dc.titleInfiltration and sustenance of viability of cells by amphiphilic biosynthetic biodegradable hydrogels
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