An X-ray micro-fluorescence study to investigate the distribution of Al, Si, P and Ca ions in the surrounding soft tissue after implantation of a calcium phosphate-mullite ceramic composite in a rabbit animal model

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dc.contributor.authorMartin, RA
dc.contributor.authorJaffer, Z
dc.contributor.authorTripathi, G
dc.contributor.authorNath, S
dc.contributor.authorMohanty, M
dc.contributor.authorFitzGerald, V
dc.contributor.authorLagarde, P
dc.contributor.authorFlank, AM
dc.contributor.authorStamboulis, A
dc.contributor.authorBasu, B
dc.date.accessioned2017-03-10T03:25:27Z
dc.date.available2017-03-10T03:25:27Z
dc.date.issued2011
dc.description.abstractSynthetic calcium phosphates, despite their bioactivity, are brittle. Calcium phosphate-mullite composites have been suggested as potential dental and bone replacement materials which exhibit increased toughness. Aluminium, present in mullite, has however been linked to bone demineralisation and neurotoxicity: it is therefore important to characterise the materials fully in order to understand their in vivo behaviour. The present work reports the compositional mapping of the interfacial region of a calcium phosphate-20 wt% mullite biocomposite/soft tissue interface, obtained from the samples implanted into the long bones of healthy rabbits according to standard protocols (ISO-10993) for up to 12 weeks. X-ray micro-fluorescence was used to map simultaneously the distribution of Al, P, Si and Ca across the ceramic-soft tissue interface. A well defined and sharp interface region was present between the ceramic and the surrounding soft tissue for each time period examined. The concentration of Al in the surrounding tissue was found to fall by two orders of magnitude, to the background level, within similar to 35 mu m of the implanted ceramic.
dc.identifier.citation22 ,11;2537-2543en_US
dc.identifier.uri10.1007/s10856-011-4428-y
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9286
dc.publisherJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
dc.subjectEngineering; Materials Science
dc.titleAn X-ray micro-fluorescence study to investigate the distribution of Al, Si, P and Ca ions in the surrounding soft tissue after implantation of a calcium phosphate-mullite ceramic composite in a rabbit animal model
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