Glutamate microinjection in the medial septum of rats decreases paradoxical sleep and increases slow wave sleep

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dc.contributor.authorMukherjee, D
dc.contributor.authorKaushik, MK
dc.contributor.authorJaryal, AK
dc.contributor.authorKumar, VM
dc.contributor.authorMallick, HN
dc.date.accessioned2017-03-10T03:26:58Z
dc.date.available2017-03-10T03:26:58Z
dc.date.issued2012
dc.description.abstractThe role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in adult male rats by microinjection of L-glutamate. Sleep-wakefulness was electrophysiologically recorded, through chronically implanted electrodes, for 2 h before the injection and 4 h after the injection. There was a decrease in paradoxical sleep during the first hour and an increase in slow wave sleep during the second hour after the injection. The present findings not only supported the lesion studies but also showed that the major role of the medial septum is to suppress paradoxical sleep. NeuroReport 23:451-456 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
dc.identifier.citation23 ,7;451-456en_US
dc.identifier.uri10.1097/WNR.0b013e3283533692
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9824
dc.publisherNEUROREPORT
dc.subjectNeurosciences & Neurology
dc.titleGlutamate microinjection in the medial septum of rats decreases paradoxical sleep and increases slow wave sleep
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