Hepatotoxicity evaluation of dextran stabilized iron oxide nanoparticles in Wistar rats
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Date
2016-06
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International Journal of Pharmaceutics
Abstract
Cellular and organ responses to nanoparticles are relevant in the context of use of nanoparticles for
biomedical applications. The purpose of the present study was to determine the potential of dextran
stabilized iron oxide nanoparticles (DIONPs) to influence hepatic uptake and consequently induce
hepatotoxic response in rats following intravenous administration. Inductively coupled plasma atomic
emission spectroscopy analysis revealed that DIONPs are rapidly taken up into the liver, progressively
broken down to iron constituents and exported into blood, with a part of it being retained in the liver. The
potential of DIONPs to induce oxidative stress response was determined by evaluating the timedependent
redox defense status. Maximum alterations in antioxidant activities were observed to occur
within a period of 7 days. However, this effect was not followed by significant increase in lipid
peroxidation or modulation of hepatic enzymes such as alkaline phosphatase, alanine aminotransferase,
aspartate aminotransferase and bilirubin levels. Overall, these data imply that the liver retains functional
integrity with a dose of 10 mg/kg DIONPs, although with brief activation of redox defenses.
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Keywords
Iron oxide nanoparticles Liver Oxidative stress Antioxidant enzymes Lipid peroxidation
Citation
Easo S L, Mohanan P V. Hepatotoxicity evaluation of dextran stabilized iron oxide nanoparticles in Wistar rats. International Journal of Pharmaceutics. 2016;509(1-2):28-34