Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair.

dc.contributor	Nair, Manitha B
dc.contributor	Varma, H K
dc.contributor	John, Annie
dc.date.accessioned	2012-12-04T11:45:37Z
dc.date.available	2012-12-04T11:45:37Z
dc.date.issued	2009
dc.description.abstract	Current treatment strategies for the repair or replacement of bone use synthetic implants with stem cells and their progeny--a new approach to address unmet medical needs. This study has evaluated the effect of a silica-coated bioactive ceramic, namely HASi in comparison to hydroxyapatite (HA) on the adhesion, proliferation and osteogenic differentiation of goat bone marrow-derived mesenchymal stem cells in vitro in a prolonged culture of 28 days. The cellular activities were significantly enhanced on HASi signifying the role of silica to stimulate osteoblast cells. The fabrication of such a 'cell-ceramic construct using autologous MSCs' is aimed for the transplantation to a large bone defect site in the goat femur model which still remains a formidable challenge in Orthopedic surgery.
dc.identifier.citation	Journal of materials science. Materials in medicine. 20 Suppl 1; ; S251-8	en_US
dc.identifier.uri	https://dspace.sctimst.ac.in/handle/123456789/1237
dc.publisher	Journal of materials science. Materials in medicine
dc.subject	Biomaterials
dc.title	Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair.