Synthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material.

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dc.contributorKrishna, Lekshmi
dc.contributorJayabalan, Muthu
dc.date.accessioned2012-12-04T11:45:26Z
dc.date.available2012-12-04T11:45:26Z
dc.date.issued2009
dc.description.abstractBiodegradable poly (caprolactone diol-co-propylene fumarate-co-ethylene glycol) amphiphilic polymer with poly (ethylene glycol) and poly (caprolactone diol) chain ends (PCL-PPF-PEG) was prepared. PCL-PPF-PEG undergoes fast setting with acrylamide (aqueous solution) by free radical polymerization and produces a crosslinked hydrogel. The cross linked and freeze-dried amphiphilic material has porous and interconnected network. It undergoes higher degree of swelling and water absorption to form hydrogel with hydrophilic and hydrophobic domains at the surface and appreciable tensile strength. The present hydrogel is compatible with L929 fibroblast cells. PCL-PPF-PEG/acrylamide hydrogel is a candidate scaffold material for tissue engineering applications.
dc.identifier.citationJournal of materials science. Materials in medicine. 20 Suppl 1; ; S115-22en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/1151
dc.publisherJournal of materials science. Materials in medicine
dc.subjectTissue Engineering
dc.titleSynthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material.
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