Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep

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dc.contributor.authorMohan, N
dc.contributor.authorGupta, V
dc.contributor.authorSridharan, BP
dc.contributor.authorMellott, AJ
dc.contributor.authorEasley, JT
dc.contributor.authorPalmer, RH
dc.contributor.authorGalbraith, RA
dc.contributor.authorKey, VH
dc.contributor.authorBerkland, CJ
dc.contributor.authorDetamore, MS
dc.date.accessioned2017-03-10T03:27:35Z
dc.date.available2017-03-10T03:27:35Z
dc.date.issued2015
dc.description.abstractBackground: The microfracture technique for cartilage repair has limited ability to regenerate hyaline cartilage. Aim: The current study made a direct comparison between microfracture and an osteochondral approach with microsphere-based gradient plugs. Materials & methods: The PLGA-based scaffolds had opposing gradients of chondroitin sulfate and beta-tricalcium phosphate. A 1-year repair study in sheep was conducted. Results: The repair tissues in the microfracture were mostly fibrous and had scattered fissures with degenerative changes. Cartilage regenerated with the gradient plugs had equal or superior mechanical properties; had lacunated cells and stable matrix as in hyaline cartilage. Conclusion: This first report of gradient scaffolds in a long-term, large animal, osteochondral defect demonstrated potential for equal or better cartilage repair than microfracture.
dc.identifier.citation10 ,6;709-728en_US
dc.identifier.uri10.2217/rme.15.38
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10062
dc.publisherREGENERATIVE MEDICINE
dc.subjectCell Biology; Engineering
dc.titleMicrosphere-based gradient implants for osteochondral regeneration: a long-term study in sheep
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