Age-related decline in the responsiveness of motor cortex to plastic forces reverses with levodopa or cerebellar stimulation

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dc.contributor.authorKishore, A
dc.contributor.authorPopa, T
dc.contributor.authorJames, P
dc.contributor.authorYahia-Cherif, L
dc.contributor.authorBacker, F
dc.contributor.authorVarughese, CL
dc.contributor.authorGovind, P
dc.contributor.authorPradeep, S
dc.contributor.authorMeunier, S
dc.date.accessioned2015-01-08T05:31:45Z
dc.date.available2015-01-08T05:31:45Z
dc.date.issued2014-11
dc.description.abstractThe plasticity of motor cortex is integral for motor memory and skills acquisition but it declines with aging. Forty healthy volunteers, across 6 decades, were tested to examine the (a) age-dependency of motor cortex responsiveness to plasticity induction, as measured from the response to paired associative stimulation (PAS) and the (b) effect of aging on the cerebellar modulation of motor cortex response to PAS. We examined if reduced dopaminergic transmission was involved in the age-related decline of response to PAS by retesting 10 of the older subjects after a single dose of levodopa. There was a substantial decline in the motor cortex response to PAS with aging, which was restored by levodopa in the older subjects. The cerebellar modulation of motor cortex response to PAS was less vulnerable to aging and a single session of cerebellar inhibition reinstated the cortical responsiveness in older subjects. Both levodopa and cerebellar inhibition can be tested for their ability to enhance motor skills acquisition and motor performance in the elderly individuals.en_US
dc.identifier.citationNeurobiology of aging. 2014;35(11):2541-51en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.neurobiolaging.2014.05.004
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2278
dc.publisherNeurobiology of agingen_US
dc.subjectAging; Cerebellum; Levodopa; Motor cortex; Plasticityen_US
dc.titleAge-related decline in the responsiveness of motor cortex to plastic forces reverses with levodopa or cerebellar stimulationen_US
dc.typeArticleen_US
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