Rate and risk of all cause mortality among people with known hypertension in a rural community of southern Kerala, India:The resutls for the prolife cohort.
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
International journal of preventive medicine.
Abstract
Background: Hypertension is one of the most important
determinants of death due to vascular damage and is fast emerging
as a high burden disease in India. However, its documentation is
poor in the country. This study aims to estimate the rate and the
causal pattern of mortality in a cohort of people with high blood
pressure as compared to normotensives.
Methods: The study setting is Varkkala, a rural village in southern
Kerala, India, and the study design was that of a prospective
cohort. A total of 77,881 participants of age 20 years and above
were considered for analysis. The rate and risk of all cause
mortality (death due to any cause) among hypertensives were
quantified and compared against the normotensives. The causes
of death were also analyzedin both the groups. Cox proportional
hazard models were created to estimate the hazard ratios of death
among hypertensives adjusted for sociodemographic factors,
behaviors, and comorbidities.
Results: The incidence proportion of deaths in the study was
4.28% during the follow‑up period of 6 years. The relative risk
of mortality was 3.13 (CI: 2.91‑3.37) in the high BP group. The
age‑adjusted hazard ratio of all cause mortality for the high BP
group was 2.96 (2.56‑3.42). Coronary artery disease was the major
cause of death among the subjects with high BP.
Conclusions: The study revealed high prevalence of hypertension
in the study population. A person with hypertension is at three
times higher risk of death due to any cause compared to a
normotensive individual even after adjustment for age.
Description
Keywords
All cause mortality, hypertension, hypertension and death, hypertension in Kerala
Citation
International journal of preventive medicine. 2014; 5(5): 596– 603.