Characterizing the biocompatibility and tumor-imaging capability of Cu2S nanocrystals in vivo

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dc.contributor.authorPoulose, AC
dc.contributor.authorVeeranarayanan, S
dc.contributor.authorMohamed, MS
dc.contributor.authorSakamoto, Y
dc.contributor.authorHirosawa, N
dc.contributor.authorSuzuki, Y
dc.contributor.authorZhang, MF
dc.contributor.authorYudasaka, M
dc.contributor.authorRadhakrishnan, N
dc.contributor.authorMaekawa, T
dc.contributor.authorMohanan, PV
dc.contributor.authorKumar, DS
dc.date.accessioned2017-03-10T03:25:54Z
dc.date.available2017-03-10T03:25:54Z
dc.date.issued2015
dc.description.abstractMultifunctional nanomaterial-based probes have had key impacts on high-resolution and high-sensitivity bioimaging and therapeutics. Typically, NIR-absorbing metal sulfide-based nanocrystals (NCs) are highly assuring due to their unique optical properties. Yet, their in vivo behavior remains undetermined, which in turn undermines their potential bioapplications. Herein, we have examined the application of PEGylated Cu2S NCs as tumor contrast optical nanoprobes as well as investigated the short-and long-term in vivo compatibility focusing on anti-oxidant defense mechanism, genetic material, immune system, and vital organs. The studies revealed an overall safe profile of the NCs with no apparent toxicity even at longer exposure periods. The acquired observations culminate into a set of primary safety data of this nano-material and the use of PEGylated Cu2S NCs as promising optical nanoprobes with immense futuristic bioapplications.
dc.identifier.citation7 ,30;13061-13074en_US
dc.identifier.uri10.1039/c5nr02572a
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9448
dc.publisherNANOSCALE
dc.subjectChemistry; Science & Technology - Other Topics; Materials Science; Physics
dc.titleCharacterizing the biocompatibility and tumor-imaging capability of Cu2S nanocrystals in vivo
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