Modified gum arabic cross-linked gelatin scaffold for biomedical applications

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dc.contributor.authorSarika, PR
dc.contributor.authorCinthya, K
dc.contributor.authorJayakrishnan, A
dc.contributor.authorAnilkumar, PR
dc.contributor.authorJames, NR
dc.date.accessioned2017-03-10T03:27:38Z
dc.date.available2017-03-10T03:27:38Z
dc.date.issued2014
dc.description.abstractThe present work deals with development of modified gum arabic cross-linked gelatin scaffold for cell culture. A new biocompatible scaffold was developed by cross-linking gelatin (Gel) with gum arabic, a polysaccharide. Gum arabic was subjected to periodate oxidation to obtain gum arabic aldehyde (GAA). GAA was reacted with gelatin under appropriate pH to prepare the cross-linked hydrogel. Cross-linking occurred due to Schiff's base reaction between aldehyde groups of oxidized gum arabic and amino groups of gelatin. The scaffold prepared from the hydrogel was characterized by swelling properties, degree of cross-linking, in vitro degradation and scanning electron microscopy (SEM). Cytocompatibility evaluation using L-929 and HepG2 cells confirmed non-cytotoxic and non-adherent nature of the scaffold. These properties are essential for generating multicellular spheroids and hence the scaffold is proposed to be a suitable candidate for spheroid cell culture. (C) 2014 Elsevier B.V. All rights reserved.
dc.identifier.citation43 ,;272-279en_US
dc.identifier.uri10.1016/j.msec.2014.06.042
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10076
dc.publisherMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
dc.subjectMaterials Science
dc.titleModified gum arabic cross-linked gelatin scaffold for biomedical applications
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