In vitro studies on the effect of physical cross-linking on the biological performance of aliphatic poly(urethane urea) for blood contact applications

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dc.contributorThomas, V
dc.contributorKumari, TV
dc.contributorJayabalan, M
dc.date.accessioned2012-12-04T11:44:20Z
dc.date.available2012-12-04T11:44:20Z
dc.date.issued2001
dc.description.abstractThe effect of physical cross-Linking in candidate cycloaliphatic and hydrophobic poly(urethane urea) (4,4'-methylenebis(cyclohexylisocyanate), H12MDI/hydroxy-terminated polybutadiene, HTPBD/hexamethylene-diamine, HDA) and poly(ether urethane urea)s (H12MDI/HTPBD-PTMG/HDA) on the in vitro calcification and blood-material interaction was studied. All the candidate poly(urethane urea)s and poly(ether urethane urea)s elicit acceptable hemolytic activity, cytocompatibility, calcification, and blood compatibility in vitro. The studies on blood-material interaction reveal that the present poly(urethane urea)s are superior to polystyrene microtiter plates which were used for the studies on blood-material interaction. The present investigation reveals the influence of physical cross-link density on biological interaction differently with poly(urethane urea) and poly(ether urethane urea)s. The higher the physical cross-link density in the poly(urethane urea)s, the higher the calcification and consumption of WBC in whole blood. On the other hand, the higher the physical cross-link density in the poly(ether urethane urea)s, the lesser the calcification and consumption of WBC in whole blood. However a reverse of the above trend has been observed with the platelet consumption in the poly(urethane urea)s and poly(ether urethane urea)s.
dc.identifier.citationBIOMACROMOLECULES. 2; 2; 588-596en_US
dc.identifier.urihttp://dx.doi.org/10.1021/bm010044f
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/616
dc.publisherBIOMACROMOLECULES
dc.subjectBiocompatibility
dc.titleIn vitro studies on the effect of physical cross-linking on the biological performance of aliphatic poly(urethane urea) for blood contact applications
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