Immortalization and characterization of porcine ventricular endocardial endothelial cells

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dc.contributorKuruvilla, Leena
dc.contributorSanthoshkumar, T. R.
dc.contributorKartha, Chandrasekharan Cheranellore
dc.date.accessioned2012-12-04T11:44:18Z
dc.date.available2012-12-04T11:44:18Z
dc.date.issued2007
dc.description.abstractEndocardial endothelial cells (EECs), which form the inner lining of the cavities of the heart, are a distinct cell population whose dysfunction can be critical in pathological conditions of heart. Insights into the role and organization of these cells in pathological states of the heart are limited mainly due to a dearth of experimental models. To date no endocardial endothelial cell line is available. The authors attempted to immortalize porcine ventricular EECs by transfecting the cells with human telomerase reverse transcriptase (hTERT). EECs immortalized by ectopic expression of hTERT exhibit phenotypic and functional characteristics similar to primary EECs. The EE cell line could be useful for the study of mechanisms involved in the interaction of EECs with the underlying myocardium and cardiac interstitium and as useful tools in understanding their role in diseased states of heart.
dc.identifier.citationENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH. 14; 1; 35-43en_US
dc.identifier.urihttp://dx.doi.org/10.1080/10623320601177353
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/601
dc.publisherENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH
dc.subjectCardiology
dc.titleImmortalization and characterization of porcine ventricular endocardial endothelial cells
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