TANTALUM-LOADED POLYURETHANE MICROSPHERES FOR PARTICULATE EMBOLIZATION - PREPARATION AND PROPERTIES

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dc.contributorTHANOO, BC
dc.contributorSUNNY, MC
dc.contributorJAYAKRISHNAN, A
dc.date.accessioned2012-12-04T11:45:28Z
dc.date.available2012-12-04T11:45:28Z
dc.date.issued1991
dc.description.abstractPolyurethane microspheres having diameters in the range 150-1500-mu-m were prepared by condensation polymerization of toluene diisocyanate (TDI) with poly(tetramethylene glycol) (PTMG) of average mol wt 990 in an aqueous dispersion medium containing dioctyl sulphosuccinate (DOS) as the suspension stabilizer and 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst for polymerization. Incorporation of tantalum powder in the polymerizing phase led to the formation of Ta-loaded microspheres with good radiopacity. Microspheres were surface-modified by grafting methacrylic acid (MA) on to them using gamma-radiation from a Co60 source. Conversion of the grafted MA into its sodium salt imparted hydrophilicity and slipperiness to the microspheres enabling them to pass through Teflon(R) cathers without obstructing the catheter lumen. These microspheres may find application as radiopaque embolization agents.
dc.identifier.citationBIOMATERIALS. 12; 5; 525-528en_US
dc.identifier.urihttp://dx.doi.org/10.1016/0142-9612(91)90154-3
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/1165
dc.publisherBIOMATERIALS
dc.subjectBiomaterials
dc.titleTANTALUM-LOADED POLYURETHANE MICROSPHERES FOR PARTICULATE EMBOLIZATION - PREPARATION AND PROPERTIES
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