DETECTION OF MYCOBACTERIUM-TUBERCULOSIS ANTIGEN-5 IN CEREBROSPINAL-FLUID BY INHIBITION ELISA AND ITS DIAGNOSTIC POTENTIAL IN TUBERCULOUS MENINGITIS

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dc.contributorRADHAKRISHNAN, VV
dc.contributorMATHAI, A
dc.date.accessioned2012-12-04T11:43:48Z
dc.date.available2012-12-04T11:43:48Z
dc.date.issued1991
dc.description.abstractInhibition ELISA was used to quantitate Mycobacterium tuberculosis antigen 5 in cerebrospinal fluid (CSF) specimens of 40 patients with a clinical diagnosis of tuberculous meningitis. In all 10 culture-proven patients, the assay was positive; in 30 culture-negative patients, the assay yielded positive results for 21. CSF antigen 5 concentrations ranged from 9 to 82 ng/ml (mean +/- SD, 45.5 +/- 6.2). In 40 patients with nontuberculous neurologic diseases, mean concentration was 1.45 ng/ml. Thus, inhibition ELISA for the detection of M. tuberculosis antigen 5 in CSF has definite diagnostic potential during the active phase of the disease and should be a routine diagnostic test, particularly when bacteriologic cultures in CSF are negative for M. tuberculosis.
dc.identifier.citationJOURNAL OF INFECTIOUS DISEASES. 163; 3; 650-652en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/338
dc.publisherJOURNAL OF INFECTIOUS DISEASES
dc.subjectLaboratory Diagnosis
dc.titleDETECTION OF MYCOBACTERIUM-TUBERCULOSIS ANTIGEN-5 IN CEREBROSPINAL-FLUID BY INHIBITION ELISA AND ITS DIAGNOSTIC POTENTIAL IN TUBERCULOUS MENINGITIS
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