Biodegradation and cytocompatibility studies of a triphasic ceramic-coated porous hydroxyapatite for bone substitute applications

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dc.contributor.authorJohn, A
dc.contributor.authorNair, MB
dc.contributor.authorVarma, HK
dc.contributor.authorBernhardt, A
dc.contributor.authorGelinsky, M
dc.date.accessioned2017-03-10T03:25:40Z
dc.date.available2017-03-10T03:25:40Z
dc.date.issued2008
dc.description.abstractBone defects due to trauma or disease have led to the need for biomaterials as substitutes for tissue regeneration and repair. Herein, we introduce a porous triphasic ceramic-coated hydroxyapatite scaffold (HASi) for such applications. Interestingly, in the degradation experiments with isotonic buffer, HASi showed a significant release of silica with the disappearance of the tricalcium phosphate phase. Furthermore, the material also exhibited cytocompatibility with cultured bone marrow-derived mesenchymal stem cells of human origin. The material chemistry, together with the favorable cellular characteristics, indicates HASi as a promising candidate for critical-size bony defects, which still remains a formidable clinical challenge in the orthopedic scenario.
dc.identifier.citation5 ,1;11-19en_US
dc.identifier.uri10.1111/j.1744-7402.2008.02191.x
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9368
dc.publisherINTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
dc.subjectMaterials Science
dc.titleBiodegradation and cytocompatibility studies of a triphasic ceramic-coated porous hydroxyapatite for bone substitute applications
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