Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing
| dc.contributor.author | Radhakumary, C | |
| dc.contributor.author | Antonty, M | |
| dc.contributor.author | Sreenivasan, K | |
| dc.date.accessioned | 2017-03-10T03:26:20Z | |
| dc.date.available | 2017-03-10T03:26:20Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | There is a demand for a wound dressing which can be removed from the application site easily without causing any pain or discomfort A material removable by manipulating the temperature (e g moisten with ice cold water) from that point of view seems to have considerable potential Here we report a new formulation consisting of thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin The thermoresponsive material was cytocompatible and was found to modulate the release of the incorporated ciprofloxacin in a sustained fashion reflecting its suitability to protect a wound for a prolonged period The film exhibited adequate mechanical strength and was removable from a substrate (e g tissue culture plate) by lowering the temperature The combination of thiolated chitosan with poly(N-isopropyl acrylamide) and ciprofloxacin showed antibacterial properties to the virulent bacteria E colt supporting its potential as a wound dressing (C) 2010 Elsevier Ltd All rights reserved | |
| dc.identifier.citation | 83 ,2;705-713 | en_US |
| dc.identifier.uri | 10.1016/j.carbpol.2010.08.042 | |
| dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/9614 | |
| dc.publisher | CARBOHYDRATE POLYMERS | |
| dc.subject | Chemistry; Polymer Science | |
| dc.title | Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing |