Structural and metabolic changes in the brain of patients with upper motor neuron disorders: A multiparametric MRI study

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dc.contributor.authorCharil, A
dc.contributor.authorCorbo, M
dc.contributor.authorFilippi, M
dc.contributor.authorKesavadas, C
dc.contributor.authorAgosta, F
dc.contributor.authorMunerati, E
dc.contributor.authorGambini, A
dc.contributor.authorComi, G
dc.contributor.authorScotti, G
dc.contributor.authorFalini, A
dc.date.accessioned2017-03-10T03:28:38Z
dc.date.available2017-03-10T03:28:38Z
dc.date.issued2009
dc.description.abstractOur objective was to assess and compare the diagnostic sensitivity of conventional MRI (cMRI), magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI), and proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Thirty-eight ALS patients, nine PLS patients, and 22 healthy controls were enrolled. cMRI, MTI, DWI and (1)H-MRSI were obtained. ALS patients were classified as advanced phase (Ap)-ALS (definite + probable) and early phase (Ep)-ALS (possible + probable-laboratory supported). cMRI was highly sensitive in detecting corticospinal tract (CST) hyperintensities in Ap-ALS (63.4%) and PLS (71.9%), but it was poorly sensitive in Ep-ALS (17.1%). Hyperintensity on proton density-weighted images correlated with ALS severity (p = 0.02). CST apparent diffusion coefficient was significantly increased in ALS (p < 0.01) and PLS (p = 0.02) versus controls. The N-acetylaspartate/ creatine ratio was significantly reduced in the motor cortex of patients versus controls(p <= 0.01 in PLS, p = 0.02 in Ap-ALS). The study shows the utility of cMRI for diagnosing ALS. Nevertheless, MRI sensitivity is limited at the early stages of the disease. In these cases, DWI and (1)H-MRSI seem to have the potential to ameliorate the patients' work-up and estimate the nature and extent of the underlying pathological damage.
dc.identifier.citation10 ,42891;269-279en_US
dc.identifier.uri10.3109/17482960902777339
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10465
dc.publisherAMYOTROPHIC LATERAL SCLEROSIS
dc.subjectNeurosciences & Neurology
dc.titleStructural and metabolic changes in the brain of patients with upper motor neuron disorders: A multiparametric MRI study
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