ULTRASTRUCTURE OF ORAL SQUAMOUS-CELL CARCINOMA - A COMPARATIVE-ANALYSIS OF DIFFERENT HISTOLOGICAL TYPES
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Date
1994
Journal Title
Journal ISSN
Volume Title
Publisher
ORAL ONCOLOGY-EUROPEAN JOURNAL OF CANCER PART B
Abstract
Twenty-five oral carcinomas and five normal oral epithelial specimens were studied using light and electron microscopy. All histological types (well differentiated squamous cell carcinoma, moderately differentiated squamous cell carcinoma, poorly differentiated squamous cell carcinoma, verrucous carcinoma and spindle cell carcinoma) were seen in the study sample. In addition, 1 case of carcinoma in situ was also present. The normal oral epithelium consisted of three keratinising types (gingiva) and two non-keratinising types (buccal mucosa). The ultrastructural features of oral carcinomas showed good correlation with the features seen in light microscopy. The differentiation status of the lesions showed a relationship with cell and nuclear size, tonofilament and keratin content as well as few other cellular abnormalities. It was also observed that the fine details revealed by electron microscopy were often a means of explaining the characteristic histopathological features of oral carcinoma.
Description
Keywords
Oncology; Dentistry, Oral Surgery & Medicine
Citation
30B ,1;32-42