Model of cardiovascular injury in magnesium deficiency

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dc.contributorShivakumar, K
dc.date.accessioned2012-12-04T11:44:38Z
dc.date.available2012-12-04T11:44:38Z
dc.date.issued2001
dc.description.abstractMagnesium deficiency is known to produce cardiovascular lesions. It is, however, not clear as to what constitutes magnesium deficiency - reduced serum levels, reduced tissue levels or reduced intracellular levels of the ionic form of the element. This article cites evidence in support of a hypothesis that a fall in serum magnesium levels may trigger a temporal sequence of events involving vasoconstriction, hemodynamic alterations and vascular endothelial injury to produce pro-inflammatory, pro-oxidant and pro-fibrogenic effects, resulting in initial perivascular myocardial fibrosis which, in turn, would cause myocardial damage and replacement fibrosis. Further, angiotensin II may be the prime mover of the pathogenetic cascade in magnesium deficiency. Importantly, such a mechanism of cardiovascular injury would be independent of a reduction in myocardial or vascular tissue levels of magnesium. (C) 2001 Harcourt Publishers Ltd.
dc.identifier.citationMEDICAL HYPOTHESES. 56; 1; 110-113en_US
dc.identifier.urihttp://dx.doi.org/10.1054/mehy.2000.1123
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/11133266
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/751
dc.publisherMEDICAL HYPOTHESES
dc.subjectExperimental Medicine
dc.titleModel of cardiovascular injury in magnesium deficiency
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