Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats
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Date
2000
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
JOURNAL OF MICROENCAPSULATION
Abstract
An oral formulation based on liposome encapsulated alginate-chitosan gel capsules was developed for insulin delivery for the treatment of diabetes. Liposome encapsulation helped to increase the encapsulation efficiency of insulin in alginate-chitosan capsules. This formulation delivers insulin in the neutral environment of the intestine, by-passing the acidic media in the stomach, with increased drug absorption and bioavailability. Oral administration of this formulation was found to reduce blood glucose levels when tested in diabetic rats.
Description
Keywords
Chemistry; Engineering; Pharmacology & Pharmacy
Citation
17 ,4;405-411