Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapy

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dc.contributor.authorJibin, K
dc.contributor.authorVictor, M
dc.contributor.authorSaranya, G
dc.contributor.authorHema, S
dc.contributor.authorMurali, V
dc.contributor.authorMaiti, KK
dc.contributor.authorJayasree, RS
dc.date.accessioned2021-10-01T09:15:16Z
dc.date.available2021-10-01T09:15:16Z
dc.date.issued2021-07
dc.description.abstractTarget-specific reactive oxygen species (ROS)-based cancer treatments with high therapeutic efficacy and minimal side effects have been identified recently as a potentially effective cancer management strategy. Herein, we report the fabrication of a targeted nanotheranostic agent built on an iron oxide nanoparticle-decorated graphene–gold hybrid [plasmonic magnetic nanoprobe (PMNP)] for self-guided magnetic resonance (MR)/surface-enhanced Raman scattering imaging and photothermal therapy (PTT)/chemodynamic therapy (CDT). In the presence of glutathione, which is abundant in the tumor environment, the iron oxide nanoparticles undergo in situ reduction, which in turn generates hydroxyl radicals via a Fenton reaction to realize targeted destruction of tumor cells. Moreover, the localized production of heat benefited from the near-infrared absorption of the PMNP accelerates the intratumoral ROS generation process, with a synergistic effect of CDT/PTT. Furthermore, the probe offers an accurate visualization of the intracellular localization of the material through SERS/MR dual imaging channels. In view of the advantages offered by the tumor-specific stimuli-responsive nature of the probe, the PMNP presents as an effective tool for cancer management.en_US
dc.identifier.citationJibin K, Victor M, Saranya G, Hema S, Murali V, Maiti KK, Jayasree RS. Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapy. ACS Applied Biomaterials. 2021 Jul; 4(7): 5742–5752en_US
dc.identifier.urihttps://doi.org/10.1021/acsabm.1c00510
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/11066
dc.publisherACS Applied Biomaterialsen_US
dc.titleNanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapyen_US
dc.typeArticleen_US
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