Conjugation of curcumin onto alginate enhances aqueous solubility and stability of curcumin

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dc.contributor.authorDey, S
dc.contributor.authorSreenivasan, K
dc.date.accessioned2015-02-16T09:11:04Z
dc.date.available2015-02-16T09:11:04Z
dc.date.issued2015-01
dc.description.abstractCurcumin is a potential drug for various diseases including cancer. Prime limitations associated with curcumin are low water solubility, rapid hydrolytic degradation and poor bioavailability. In order to redress these issues we developed Alginate-Curcumin (Alg-Ccm) conjugate which was characterized by FTIR and (1)H NMR spectroscopy. The conjugate self-assembled in aqueous solution forming micelles with an average hydrodynamic diameter of 459 ± 0.32 nm and negative zeta potential. The spherical micelles were visualized by TEM. The critical micelle concentration (CMC) of Alg-Ccm conjugate was determined. A significant enhancement in the aqueous solubility of curcumin was observed upon conjugation with alginate. Formation of micelles improved the stability of curcumin in water at physiological pH. The cytotoxic activity of Alg-Ccm was quantified by MTT assay using L-929 fibroblast cells and it was found to be potentially cytotoxic. Hence, Alg-Ccm could be a promising drug conjugate as well as a nanosized delivery vehicle.en_US
dc.identifier.citationCarbohydrate Polymers. 2014;99:499-507.en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.carbpol.2013.08.06
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2353
dc.publisherCarbohydrate Polymersen_US
dc.subject(Alg); (Ccm); Alginate; CMC; Curcumin; Cytotoxicity; Polymer-drug conjugates; alginate; curcuminen_US
dc.titleConjugation of curcumin onto alginate enhances aqueous solubility and stability of curcuminen_US
dc.typeArticleen_US
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