Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes
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2016-12
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Biointerphases
Abstract
Iron oxide nanoparticles present an attractive choice for carcinogenic cell destruction via
hyperthermia treatment due to its small size and magnetic susceptibility. Dextran stabilized iron
oxide nanoparticles (DIONPs) synthesized and characterized for this purpose were used to evaluate
its effect on cellular uptake, cytotoxicity, and oxidative stress response in human peripheral blood
lymphocytes. In the absence of efficient internalization and perceptible apoptosis, DIONPs were
still capable of inducing significant levels of reactive oxygen species formation shortly after
exposure. Although these particles did not cause any genotoxic effect, they enhanced the
expression of a few relevant oxidative stress and antioxidant defense related genes, accompanied
by an increase in the glutathione peroxidase activity. These results indicate that under the tested
conditions, DIONPs induced only minimal levels of oxidative stress in lymphocytes.
Understanding the biological interaction of DIONPs, the consequences as well as the associated
mechanisms in vitro, together with information obtained from systemic studies, could be expected
to advance the use of these particles for further clinical trials
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Easo SL, Mohanan PV. Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes. Biointerphases. 2016;11(4).