Alginate-polyester comacromer based hydrogels as physiochemically and biologically favorable entities for cardiac tissue engineering
dc.contributor.author | Thankam, FG | |
dc.contributor.author | Muthu, J | |
dc.date.accessioned | 2017-03-10T03:25:23Z | |
dc.date.available | 2017-03-10T03:25:23Z | |
dc.date.issued | 2015 | |
dc.description.abstract | The physiochemical and biological responses of tissue engineering hydrogels are crucial in determining their desired performance. A hybrid comacromer was synthesized by copolymerizing alginate and poly(mannitol fumarate-co-sebacate) (pFMSA). Three bimodal hydrogels pFMSA-AA, pFMSA-MA and pFMSA-NMBA were synthesized by crosslinking with Ca2+ and vinyl monomers acrylic acid (AA), methacrylic acid (MA) and N,N'-methylene bisacrylamide (NMBA), respectively. Though all the hydrogels were cytocompatible and exhibited a normal cell cycle profile, pFMSA-AA exhibited superior physiochemical properties viz non-freezable water content (58.34%) and water absorption per unit mass (0.97 g water/g gel) and pore length (19.92 +/- 3.91 mu m) in comparing with other two hydrogels. The increased non-freezable water content and water absorption of pFMSA-AA hydrogels greatly influenced its biological performance, which was evident from long-term viability assay and cell cycle proliferation. The physiochemical and biological favorability of pFMSA-AA hydrogels signifies its suitability for cardiac tissue engineering. (C) 2015 Elsevier Inc. All rights reserved. | |
dc.identifier.citation | 457 ,;52-61 | en_US |
dc.identifier.uri | 10.1016/j.jcis.2015.06.034 | |
dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/9255 | |
dc.publisher | JOURNAL OF COLLOID AND INTERFACE SCIENCE | |
dc.subject | Chemistry | |
dc.title | Alginate-polyester comacromer based hydrogels as physiochemically and biologically favorable entities for cardiac tissue engineering |