Alginate-polyester comacromer based hydrogels as physiochemically and biologically favorable entities for cardiac tissue engineering

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dc.contributor.authorThankam, FG
dc.contributor.authorMuthu, J
dc.date.accessioned2017-03-10T03:25:23Z
dc.date.available2017-03-10T03:25:23Z
dc.date.issued2015
dc.description.abstractThe physiochemical and biological responses of tissue engineering hydrogels are crucial in determining their desired performance. A hybrid comacromer was synthesized by copolymerizing alginate and poly(mannitol fumarate-co-sebacate) (pFMSA). Three bimodal hydrogels pFMSA-AA, pFMSA-MA and pFMSA-NMBA were synthesized by crosslinking with Ca2+ and vinyl monomers acrylic acid (AA), methacrylic acid (MA) and N,N'-methylene bisacrylamide (NMBA), respectively. Though all the hydrogels were cytocompatible and exhibited a normal cell cycle profile, pFMSA-AA exhibited superior physiochemical properties viz non-freezable water content (58.34%) and water absorption per unit mass (0.97 g water/g gel) and pore length (19.92 +/- 3.91 mu m) in comparing with other two hydrogels. The increased non-freezable water content and water absorption of pFMSA-AA hydrogels greatly influenced its biological performance, which was evident from long-term viability assay and cell cycle proliferation. The physiochemical and biological favorability of pFMSA-AA hydrogels signifies its suitability for cardiac tissue engineering. (C) 2015 Elsevier Inc. All rights reserved.
dc.identifier.citation457 ,;52-61en_US
dc.identifier.uri10.1016/j.jcis.2015.06.034
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9255
dc.publisherJOURNAL OF COLLOID AND INTERFACE SCIENCE
dc.subjectChemistry
dc.titleAlginate-polyester comacromer based hydrogels as physiochemically and biologically favorable entities for cardiac tissue engineering
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