Inherently X-ray opaque polyurethane microspheres for biomedical applications

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dc.contributor.authorKiran, S
dc.contributor.authorSunny, MC
dc.contributor.authorJoseph, R
dc.date.accessioned2017-03-10T03:27:18Z
dc.date.available2017-03-10T03:27:18Z
dc.date.issued2017
dc.description.abstractIn this work synthesis and characterization of inherently X-ray opaque, nonresorbable polyurethane microspheres with well-calibrated particles in a defined range of sizes suitable for embolization is reported. In order to impart X-ray opacity to the polyurethane, a bifunctional monomer, namely, 4,4-isopropylidenediphenol (BPA) was iodinated and this iodinated compound was used as one of the monomers during polyurethane synthesis. The resultant X-ray opaque polyurethane was converted into microspheres using an oil-in-water emulsion and solvent evaporation technique. Microspheres obtained had diameters in the range of 200-500 mu m, were noncytotoxic and free from X-ray attenuating additives. In vivo X-ray fluoroscopic imaging carried out in a rabbit cadaver model showed that these microspheres were sufficiently X-ray opaque to be visualized under fluoroscopic conditions. [GRAPHICS] .
dc.identifier.citation66 ,5;213-220en_US
dc.identifier.uri10.1080/00914037.2016.1201764
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9943
dc.publisherINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.subjectMaterials Science; Polymer Science
dc.titleInherently X-ray opaque polyurethane microspheres for biomedical applications
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