Development of segmented polyurethane elastomers with low iodine content exhibiting radiopacity and blood compatibility.
| dc.contributor | Dawlee, S | |
| dc.contributor | Jayabalan, Muthu | |
| dc.date.accessioned | 2012-12-04T11:43:50Z | |
| dc.date.available | 2012-12-04T11:43:50Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Biofunctionally active and inherently radiopaque polymers are the emerging need for biomedical applications. Novel segmented polyurethane elastomer with inherent radiopacity was prepared using aliphatic chain extender 2,3-diiodo-2-butene-1,4-diol, polyol polytetramethylene glycol and 4,4'-methylenebis(phenyl isocyanate) (MDI) for blood compatible applications. Aliphatic polyurethane was also prepared using hexamethylene diisocyanate for comparison. X-ray analysis of the polyurethanes revealed good radiopacity even at a relatively low concentration of 3% iodine in aromatic polyurethane and 10% in aliphatic polyurethane. The polyurethanes also possessed excellent thermal stability. MDI-based polyurethane showed considerably higher tensile strength than the analogous HDI-based polyurethane. MDI-based aromatic polyurethane exhibited a dynamic surface morphology in aqueous medium, resulting in the segregation of hydrophilic domains which was more conducive to anti-thrombogenic properties. The polyurethane was cytocompatible with L929 fibroblast cells, non-hemolytic, and possessed good blood compatibility. | |
| dc.identifier.citation | Biomedical materials (Bristol, England). 6; 5; 55002-55002 | en_US |
| dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/348 | |
| dc.publisher | Biomedical materials (Bristol, England) | |
| dc.subject | Biocompatibility | |
| dc.title | Development of segmented polyurethane elastomers with low iodine content exhibiting radiopacity and blood compatibility. |