Acetylsalicylic acid loaded poly(vinyl alcohol) hemodialysis membranes: Effect of drug release on blood compatibility and permeability

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dc.contributorPaul, W
dc.contributorSharma, CP
dc.date.accessioned2012-12-04T11:43:16Z
dc.date.available2012-12-04T11:43:16Z
dc.date.issued1997
dc.description.abstractMembranes developed from poly(vinyl alcohol) (PVA) have superior permeability because of the highly hydrophilic character of PVA. However, its blood compatibility needs to be further improved. For this we have developed acetylsalicylic acid (ASA, aspirin) loaded PVA membranes. It seems that the slow release of aspirin from the membrane provides a surface concentration of aspirin sufficient for partially inhibiting platelet adhesion. PVA membrane with 531 mu g cm(-2) of ASA loaded, may be selected for hemodialysis applications. This may help to reduce the amount of heparin infused during hemodialysis, thereby reducing the side-effects associated with the systemic administration of heparin.
dc.identifier.citationJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION. 8; 10; 755-764en_US
dc.identifier.urihttp://dx.doi.org/10.1163/156856297X00290
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/56
dc.publisherJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
dc.subjectDrug Delivery
dc.titleAcetylsalicylic acid loaded poly(vinyl alcohol) hemodialysis membranes: Effect of drug release on blood compatibility and permeability
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