Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats

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dc.contributor.authorRemya, NS
dc.contributor.authorSyama, S
dc.contributor.authorSabareeswaran, A
dc.contributor.authorMohanan, PV
dc.date.accessioned2017-05-07T21:46:41Z
dc.date.available2017-05-07T21:46:41Z
dc.date.issued2017-04
dc.description.abstractAlthough the toxicity/biocompatibility of hydroxyapatite nanoparticles (nano HA), a prospective nano biomaterial is extensively studied, its interaction on biological systems following chronic exposure is less exploited. In the present study, Wistar rats were given various concentrations of nano HA in the diet to determine the chronic toxicity and potential carcinogenicity. Altogether 140 rats were used for the study under various administration dosages along with control. The animals were sacrificed after 12 months of controlled continuous dosing. All in-life parameters, including body weight, food consumption, clinical observations, survival, biochemical and hematology, were unaffected by the chronic exposure of nano HA orally. Similarly, gross and histopathological evaluation was also unchanged following exposure to nano HA. No evidence of nano HA-related lesions or Nano HA-induced neoplasia was suggested in this rodent bioassay study.en_US
dc.identifier.citation. Remya NS, Syama S, Sabareeswaran A, Mohanan PV. Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats. Materials Science and Engineering C. 2017;76:518-27en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.msec.2017.03.076
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10710
dc.publisherMaterials Science and Engineeringen_US
dc.subjectNanomaterials, Hydroxyapatite, Chronic toxicity, Histopathologyen_US
dc.titleInvestigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar ratsen_US
dc.typeArticleen_US
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