Wound healing potential of scaffolds prepared from porcine jejunum and urinary bladder by a non-detergent/enzymatic method.

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dc.contributor.authorRevi, D
dc.contributor.authorVineetha, VP
dc.contributor.authorMuhamed, J
dc.contributor.authorSurendran, GC
dc.contributor.authorRajan, A
dc.contributor.authorKumary, TV
dc.contributor.authorAnilkumar, TV
dc.date.accessioned2015-05-07T04:24:24Z
dc.date.available2015-05-07T04:24:24Z
dc.date.issued2015-02
dc.description.abstractScaffolds prepared using extracellular matrices of mammalian organs/tissues, when used as grafts, have wound healing potential. This paper evaluated the physical properties and in vivo wound healing potential of jejunum-derived scaffold (JDS) and urinary bladder-derived scaffold (UDS) of porcine origin prepared by a non-detergent/enzymatic method. The former had higher flexural rigidity and suture retention strength compared to the latter, but both of them had the essential flexural rigidity and suture retention strength required for skin grafts. Full thickness skin-wounds on rabbit dorsum were treated with these scaffolds and the wound healing ability was compared by studying histomorphology parameters such as re-epithelialisation, collagen deposition, angiogenesis, proliferation of cells, mesenchymal cell infiltration and myofibroblast response. The extent of these reactions was assessed using histomorphometry. The results indicated that both grafts initiated healing faster than those wounds without any graft, as evidenced by the extent of cell proliferation and mesenchymal cell infiltration. The myofibroblast response persisted longer in the non-graft assisted wound healing reaction compared to the healing in the graft assisted wounds. Moreover, the JDS induced higher cell proliferation and greater angiogenesis than UDS probably indicating better healing by the former. The results suggested that JDS and UDS prepared by non-detergent/enzymatic method have potential clinical applications.en_US
dc.identifier.citationRevi D, Vineetha VP, Muhamed J, Surendran GC, Rajan A, Kumary TV, Anilkumar TV. Wound healing potential of scaffolds prepared from porcine jejunum and urinary bladder by a non-detergent/enzymatic method. J Biomater Appl. 2014en_US
dc.identifier.urihttp://dx.doi.org/10.1177/0885328214560218
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2394
dc.publisherJ Biomater Appl.en_US
dc.subjectExtracellular matrix; alpha smooth muscle actin; histomorphometry; proliferating cell nuclear antigen; wound healingen_US
dc.titleWound healing potential of scaffolds prepared from porcine jejunum and urinary bladder by a non-detergent/enzymatic method.en_US
dc.typeArticleen_US
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