Poly(epsilon-caprolactone) microspheres as a vaccine carrier

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dc.contributor.authorJameela, SR
dc.contributor.authorSuma, N
dc.contributor.authorMisra, A
dc.contributor.authorRaghuvanshi, R
dc.date.accessioned2017-03-10T03:28:06Z
dc.date.available2017-03-10T03:28:06Z
dc.date.issued1996
dc.description.abstractPoly(epsilon-caprolactone) (PCL), a biocompatible and biodegradable polymer hitherto thought unsuitable for protein delivery because of its poor permeability to macromolecules, is shown to be sufficiently permeable to proteins to function as a vaccine carrier, Using a model antigen such as bovine serum albumin (BSA), we demonstrate that a single injection of BSA-loaded PCL microspheres generates an immune response comparable in magnitude and time kinetics to that of a conventional three-injection schedule of the antigen in a rat model, Unlike polyesters such as poly(lactic acid) (PLA) and poly(glycolic acid) (PGA), PCL degrades slowly and therefore does not generate an acid environment adversely affecting the antigenicity of vaccines and may prove to be promising as a vaccine carrier.
dc.identifier.citation70 ,7;669-671en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10249
dc.publisherCURRENT SCIENCE
dc.subjectScience & Technology - Other Topics
dc.titlePoly(epsilon-caprolactone) microspheres as a vaccine carrier
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