Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells

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dc.contributorSuboj, Priya
dc.contributorBabykutty, Suboj
dc.contributorSrinivas, Priya
dc.contributorGopala, Srinivas
dc.date.accessioned2012-12-04T11:43:20Z
dc.date.available2012-12-04T11:43:20Z
dc.date.issued2012
dc.description.abstractAloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6. Copyright (C) 2012 S. Karger AG, Basel
dc.identifier.citationPHARMACOLOGY. 89; 40910; 91-98en_US
dc.identifier.urihttp://dx.doi.org/10.1159/000335659
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/90
dc.publisherPHARMACOLOGY
dc.subjectBiochemistry
dc.titleAloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells
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