Intravenous immunoglobulin reduces serum tumor necrosis factor alpha in patients with Guillain-Barre Syndrome

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dc.contributorReuben, S
dc.contributorSumi, MG
dc.contributorMathai, A
dc.contributorNair, MD
dc.contributorRadhakrishnan, VV
dc.date.accessioned2012-12-04T11:44:25Z
dc.date.available2012-12-04T11:44:25Z
dc.date.issued2003
dc.description.abstractBackground: Tumor necrosis factor a TNF-alpha has a possible role in the pathogenesis of the Guillain-Barre'syndrome (GBS). Alms: To study the effect of intravenous immunoglobulin (IVIg) on serum TNF-alpha concentrations in patients with GBS. Material and Methods: The effect of IVIg on TNF-alpha was evaluated in 36 patients with GBS. Serum TNF-alpha concentration was measured by enzyme-linked immunosorbent assay (ELISA). The sera of 22 (61%) patients with GBS showed elevated concentrations of TNFalpha (35-182 pg/ml) and these sera were individually incubated in vitro with IVIg (0.25mg/ml) at 370 degreesC for 24 hours. Results: The serum TNF-alpha concentrations in the 22 GBS patients with elevated levels showed a steady decline (60.34-19.78 pg/ml) following incubation with IVIg. These 22 patients also received IVIg therapy, and serum TNF-alpha concentrations showed a significant decline (65.5-9.75 pg/ml) at the end of the therapy. At the time of discharge from the hospital, there was a positive correlation between neurological recovery and decline in TNF-alpha concentrations in these 22 GBS patients. Conclusions: The results of this study indicate that elevated levels of TNF-alpha occur in a proportion of patients with GBS and in these patients elevated serum TNF-alpha levels decline with IVIg therapy.
dc.identifier.citationNEUROLOGY INDIA. 51; 4; 487-489en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/14742928
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/656
dc.publisherNEUROLOGY INDIA
dc.subjectImmunology
dc.titleIntravenous immunoglobulin reduces serum tumor necrosis factor alpha in patients with Guillain-Barre Syndrome
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