Epileptiform activity in the electroencephalogram of 6-year-old children of women with epilepsy
| dc.contributor.author | Syam, UK | |
| dc.contributor.author | Thomas, SV | |
| dc.date.accessioned | 2017-03-10T03:26:34Z | |
| dc.date.available | 2017-03-10T03:26:34Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | Purpose: To study the epileptiform discharges (EDs) in the electroencephalogram (EEG) of 6-8-year-old children of women with epilepsy (WWE). Materials and Methods: All children born to women with epilepsy and prospectively followed up through the Kerala Registry of Epilepsy and Pregnancy (KREP), aged 6-8 years, were invited (n = 532). Out of the 254 children who responded, clinical evaluations and a 30-min digital 18 channel EEG were completed in 185 children. Results: Of the 185 children examined, 37 (20%) children (19 males, 18 females) had ED in their EEG. The EDs were generalized in 7 children, and focal in 30 children. The EDs were present in the sleep record only of 16 (43%) children and in the awake record only of 6 (16%) children. Out of the 94 children for whom seizure history was available, 7 children (7.4%) had seizures (neonatal seizures: 4, febrile seizure: 1, and single nonfebrile seizure: 2) and none had history of epilepsy or recurrent nonfebrile seizures. The odds ratio (OR) for occurrence of ED in the EEG was significantly higher for children of WWE [OR = 3.5, 95% confidence interval (CI) 2.3-6.0] when compared to the published data for age-matched children of mothers without epilepsy. There was no association between the occurrence of ED and the children's maternal characteristics [epilepsy syndrome, seizures during pregnancy, maternal intelligence quotient (IQ)] or the children's characteristics [antenatal exposure to specific antiepileptic drugs (AEDs), birth weight, malformations, IQ]. Conclusion: Children of WWE have a higher risk of epileptiform activity in their EEG when compared to healthy children in the community though none had recurrent seizures. | |
| dc.identifier.citation | 19 ,3;318-322 | en_US |
| dc.identifier.uri | 10.4103/0972-2327.179974 | |
| dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/9704 | |
| dc.publisher | ANNALS OF INDIAN ACADEMY OF NEUROLOGY | |
| dc.subject | Neurosciences & Neurology | |
| dc.title | Epileptiform activity in the electroencephalogram of 6-year-old children of women with epilepsy |