Stimuli sensitive polymethacrylic acid microparticles (PMAA) - Oral insulin delivery

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dc.contributorVictor, SP
dc.contributorSharma, CP
dc.date.accessioned2012-12-04T11:45:17Z
dc.date.available2012-12-04T11:45:17Z
dc.date.issued2002
dc.description.abstractThis study investigated polymethacrylic acid (PMAA) microparticles for controlled release of Insulin in oral administration. The microparticles were characterised by scanning electron microscopy (SEM) for morphological studies. The swelling behaviour and drug release profile in various pH media were studied. The % swelling of gels was found to be inversely related to the amount of crosslinker added. Inclusion complex of betaCD and Insulin was studied using polyacrylamide gel electrophoresis (PAGE). Optimum complexation was obtained in the ratio 100 mg betaCD: 200IU Insulin. The release pattern of Insulin from Insulin-betaCD complex encapsulated PMAA microparticles showed release of Insulin for more than seven hours.
dc.identifier.citationJOURNAL OF BIOMATERIALS APPLICATIONS. 17; 2; 125-134en_US
dc.identifier.urihttp://dx.doi.org/10.1106/088532802028583
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/1080
dc.publisherJOURNAL OF BIOMATERIALS APPLICATIONS
dc.subjectDrug Delivery
dc.titleStimuli sensitive polymethacrylic acid microparticles (PMAA) - Oral insulin delivery
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