Relating pore size variation of poly (epsilon-caprolactone) scaffolds to molecular weight of porogen and evaluation of scaffold properties after degradation

Simple item page
dc.contributor.authorColumbus, S
dc.contributor.authorKrishnan, LK
dc.contributor.authorKrishnan, VK
dc.date.accessioned2015-01-09T09:01:31Z
dc.date.available2015-01-09T09:01:31Z
dc.date.issued2014-10
dc.description.abstractThe major challenge in designing a scaffold for fabricating tissue engineered blood vessels is optimization of its microstructure for supporting uniform cellular in-growth with good mechanical integrity and degradation kinetics suitable for long-term implantation. In this study, we have investigated the feasibility of varying the pore size of poly(ɛ-caprolactone) (PCL) scaffold by altering the molecular weight of porogen and studied the effect of degradation on morphological characteristics and mechanical properties of scaffolds by correlating to the extent of degradation. Scaffolds with two different pore sizes were prepared by solvent casting and particulate leaching where poly(ethylene glycol) (PEG) porogens having two molecular weights (3400 and 8000) were used and subjected to in vitro degradation in phosphate buffered saline (PBS) upto six months. Microcomputed tomography studies of scaffolds revealed narrower pore size distribution when PEG-3400 was used as porogen and had 78% pores in the 12-24 µ range, whereas incorporation of PEG-8000 resulted in broader distribution with only 65% pores in the same range. Degradation resulted in scaffolds with narrower pore size distribution to have better retention of morphological and mechanical characteristics compared to scaffolds with broader distribution. Gravimetric and molecular weight studies also showed that scaffold degradation in both cases was only in initial stages after 6 months and PCL scaffolds had potential to be recommended for vascular tissue engineering applications.en_US
dc.identifier.citationJournal of Biomedical Materials Research part B: Applied Biomaterials. 2014;102B(4):789-96en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jbm.b.33060
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2302
dc.publisherJournal of Biomedical Materials Research part B: Applied Biomaterials.en_US
dc.titleRelating pore size variation of poly (epsilon-caprolactone) scaffolds to molecular weight of porogen and evaluation of scaffold properties after degradationen_US
dc.typeArticleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles