Recent advances in the oral delivery of insulin

dc.contributor.author	Rekha, MR
dc.contributor.author	Sharma, CP
dc.date.accessioned	2015-01-08T06:45:13Z
dc.date.available	2015-01-08T06:45:13Z
dc.date.issued	2014-08
dc.description.abstract	Insulin was discovered over 90 years ago. However oral insulin still remains a challenging and elusive goal. Extensive efforts are being made worldwide for developing noninvasive drug delivery systems, mainly via oral route as it is the most widely accepted means of administration. The main barriers faced in oral protein delivery are the enzymatic degradation and poor permeability across the intestinal wall. The approaches for developing an oral insulin delivery system mainly focus on overcoming these barriers. To overcome the gastro-intestinal barriers various types of formulations such as insulin conjugates, permeation enhancers, micro/nanoparticles, liposomes etc. are investigated. In the recent years a number of advances have taken place in understanding the needs and workable mechanisms of improved oral peptide delivery systems. In this review the recent patents on oral insulin is focused. Emphasis is on the technologies based on permeation enhancers and nanoparticle based carrier systems.	en_US
dc.identifier.citation	Recent patents on drug delivery and formulation. 2014;8(2):155-9.	en_US
dc.identifier.uri	https://dspace.sctimst.ac.in/handle/123456789/2282
dc.publisher	Recent patents on drug delivery and formulation.	en_US
dc.title	Recent advances in the oral delivery of insulin	en_US
dc.type	Article	en_US

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