Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin
| dc.contributor | Balakrishnan, B | |
| dc.contributor | Mohanty, M | |
| dc.contributor | Fernandez, AC | |
| dc.contributor | Mohanan, PV | |
| dc.contributor | Jayakrishnan, A | |
| dc.date.accessioned | 2012-12-04T11:44:05Z | |
| dc.date.available | 2012-12-04T11:44:05Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Cyclic adenosine monophosphate (cAMP) has long been regarded as a second messenger and a regulator of human keratinocyte proliferation. To explore more effective wound management, dibutyryl cyclic adenosine monophosphate (DBcAMP), a lipophilic analog of cAMP was incorporated into an in situ-forming hydrogel wound dressing based on periodate-oxidized alginate and gelatin. In vitro release of DBcAMP from the matrix into phosphate buffered saline was slow and increased with time. Only 50-60% of the compound was released into the medium over a period of 2 days suggestive of a sustained release into the wound bed over a period of few days. The wound-healing efficacy of the DBcAMP-incorporated dressing was evaluated on experimental full-thickness wounds in a rat model. It was found that dressing promoted wound healing leading to complete re-epithelialization of wounds within 10 days, whereas control wounds took 15 days for complete re-epithelialization. Data obtained in this Study showed that the presence of DBcAMP accelerated healing and re-epithelialization of full-thickness wounds. (c) 2005 Elsevier Ltd. All rights reserved. | |
| dc.identifier.citation | BIOMATERIALS. 27; 8; 1355-1361 | en_US |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.biomaterials.2005.08.021 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/16146648 | |
| dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/484 | |
| dc.publisher | BIOMATERIALS | |
| dc.subject | Biological Evaluation | |
| dc.title | Evaluation of the effect of incorporation of dibutyryl cyclic adenosine monophosphate in an in situ-forming hydrogel wound dressing based on oxidized alginate and gelatin |