Morphological & ultrastructural changes of platelet concentrates stored in PVC bags

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dc.contributorKrishnan, LK
dc.contributorSulochana, PV
dc.contributorMathai, J
dc.contributorJohn, A
dc.contributorSivakumar, R
dc.date.accessioned2012-12-04T11:44:38Z
dc.date.available2012-12-04T11:44:38Z
dc.date.issued1997
dc.description.abstractTo assess the effect of storage bags on platelets, we studied the morphological and ultrastructural changes of samples drawn from platelet concentrates (PC) prepared and stored in triple, poly vinyl chloride (PVC) bags, manufactured in India. Using the scanning electron microscopy, we demonstrate formation of long pseudopods, and interaction through these to form aggregates. When platelets were stored at 23+/-2 degrees C, morphological changes were severe compared to the deleterious effects when kept at 22+/-0.5 degrees C. Ultrastructural analysis also showed that maintenance of discoid shape and prevention of granule secretion could be improved by storing the platelets at 22+/-0.5 degrees C. Significant degree of platelet fragmentation took place when the storage temperature was high. The morphology score done for platelets stored st both 22+/-0.5 degrees C and 23+/-2 degrees C showed that preservation of discoid shape was better with the former.
dc.identifier.citationINDIAN JOURNAL OF MEDICAL RESEARCH. 105; ; 77-84en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/9055500
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/759
dc.publisherINDIAN JOURNAL OF MEDICAL RESEARCH
dc.subjectHematology
dc.titleMorphological & ultrastructural changes of platelet concentrates stored in PVC bags
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