Lack of association of Lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population

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dc.contributor.authorSathyan, S
dc.contributor.authorKoshy, L
dc.contributor.authorLekshmi, KRS
dc.contributor.authorEaswer, HV
dc.contributor.authorPremkumar, S
dc.contributor.authorAlapatt, JP
dc.contributor.authorNair, S
dc.contributor.authorBhattacharya, RN
dc.contributor.authorBanerjee, M
dc.date.accessioned2017-03-10T03:27:24Z
dc.date.available2017-03-10T03:27:24Z
dc.date.issued2013
dc.description.abstractIntracranial aneurysm (IA) accounts for 85 % of haemorrhagic stroke and is mainly caused due to weakening of arterial wall. Lysyl oxidase (LOX) is a cuproenzyme involved in cross linking structural proteins collagen and elastin, thus providing structural stability to artery. Using a case-control study design, we tested the hypothesis whether the variants in LOX gene flanking the two LD block, can increase risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. SNPs were genotyped by fluorescence-based competitive allele-specific PCR (KASPar) chemistry. We selected 200 radiologically confirmed aneurysmal cases and 235 ethnically and age and gender matched controls from the Dravidian Malayalam speaking population of South India. We observed marked interethnic differences in the genotype distribution of LOX variants when compared to Japanese and African populations. However, there was no significant association with any of the LOX variants with IA. This study also could not observe any significant role of LOX polymorphisms in influencing IA either directly or indirectly through its confounding factors such as hypertension and gender in South Indian population.
dc.identifier.citation40 ,10;5869-5874en_US
dc.identifier.uri10.1007/s11033-013-2693-1
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9985
dc.publisherMOLECULAR BIOLOGY REPORTS
dc.subjectBiochemistry & Molecular Biology
dc.titleLack of association of Lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population
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