Metallocene based polyolefin: a potential candidate for the replacement of flexible poly (vinyl chloride) in the medical field

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dc.contributor.authorSunny, MC
dc.contributor.authorRamesh, P
dc.contributor.authorMohanan, PV
dc.contributor.authorGeorge, KE
dc.date.accessioned2017-03-10T03:27:35Z
dc.date.available2017-03-10T03:27:35Z
dc.date.issued2010
dc.description.abstractA comparative assessment of the performance properties of metallocene polyolefin (m-PO) with those of plasticized poly (vinyl chloride) (pPVC) and ethylene vinyl acetate (EVA) copolymer having 18% vinyl acetate content (EVA-18), the two common polymers used for flexible medical products, is carried out. The preliminary evaluation of the processability, mechanical properties, and thermal stability of the new material, m-PO is described. The processability parameters like mixing torque and melt viscosity of m-PO are found to be comparable with those of pPVC and EVA-18. Mechanical properties such as tensile strength, elongation at break, and tear strength (TS) of m-PO are much higher than that of pPVC and EVA-18. Thermo gravimetric analysis (TGA) indicates that the thermal degradation of m-PO takes place only at temperatures above 340 degrees C and can be processed at 170 degrees C without much damage. Oxygen and carbon dioxide permeabilities of m-PO at three different temperatures (10, 25, and 40 degrees C) are evaluated and compared with those of pPVC and EVA-18. It could be seen that the permeabilities of both the gases for m-PO at three temperatures were lower than those of pPVC and EVA. Biological evaluation of m-PO is carried out by assessing its cytotoxicity, hemolytic property, and blood clotting initiation. The cytotoxicity studies indicate that m-PO is non-toxic to the monolayer of L929 mammalian fibroblast cell lines on direct contact or the exposure of its extract. Non-hemolytic property of m-PO by direct contact as well as test on extract is revealed both in static and in dynamic conditions. Blood clotting time experiments indicate that the initiation of blood clotting due to m-PO is faster than that of pPVC and EVA-18. Copyright (C) 2009 John Wiley & Sons, Ltd.
dc.identifier.citation21 ,9;621-631en_US
dc.identifier.uri10.1002/pat.1475
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10058
dc.publisherPOLYMERS FOR ADVANCED TECHNOLOGIES
dc.subjectPolymer Science
dc.titleMetallocene based polyolefin: a potential candidate for the replacement of flexible poly (vinyl chloride) in the medical field
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